Info: In Utero Exposure to Bioactive Food Components and Mammary Cancer Risk

In Utero Exposure to Bioactive Food Components and Mammary Cancer Risk

Published on AidPage by IDILOGIC on Jun 24, 2005

Data sources: Catalog of Federal Domestic Assistance (CFDA), Grants.gov

Administered by:

Department of Health and Human Services, National Institutes of Health, National Institutes of Health
(see all US Federal Agencies)

Explore all postings for this grant program:

Original Grant - Mar 1, 2005

Applications Due:

Multiple Receipt Dates - See Link to Full Announcement for details.

total funding:	Not Available
max award:	none
min award:	none
cost sharing, matching:	No
number of awards:	Not Available
type of funding:	Grant

Description:

The purpose of this initiative is to invite innovative preclinical R01 and R21 applications that promote research that will enhance the understanding of the relationship between exposures to bioactive food components and/or environmental chemicals in utero , hormonal and growth factor response, gene expression or epigenetic changes and subsequent mammary cancer risk in preclinical models. Although much evidence suggests that dietary components are linked to cancer prevention, the specific nutrients, sites of action, and role of exposure in utero remain elusive. Similarly there are data suggesting a role for environmental agents such as mycotoxins, heterocyclic amines, and environmental chemicals with endocrine activity in the etiology of mammary cancer but the doses, windows of susceptibility and mechanisms are unclear. This funding opportunity encourages applications that apply new high-throughput genomic, epigenomic, proteomic, and metabolomic techno!
logies to determine how dietary exposures in utero influence adult breast cancer susceptibility. The resulting information will help define effective maternal dietary intervention strategies for breast cancer prevention in her offspring.